14 days: a timeline article

Denmark surrenders on the day of the attack. Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis. The Middle East respiratory syndrome (MERS) outbreak that was first reported in Saudi Arabia in 2012 was caused by another coronavirus of zoonotic origin (MERS-CoV). 14 days: a timeline article - befalcon.com Microbiol. 58, e02107-20 (2020). Lifting the mask on neurological manifestations of COVID-19. Helms, J. et al. Dis. Internet Explorer). This article was last updated on 24 May 2022 11/13 (84.6) 35.5 (31.1-38.2) 0/13 (0) After 15 days . The roughly 5,000-year-old human remains were found in graves from the Yamnaya culture, and the discovery may partially explain their rapid expansion throughout Europe. I make an entry for each date and/or time I come across in my sources. Li, L. et al. Inevitably, we have been selective based on the common themes that we feel are the most important take-home messages from the past year; therefore, to some extent, this article represents a personal perspective of our highlights of what we have learnt so far about the immunology of COVID-19. 14 days: a timeline article 14 days: a timeline article - catip.org.pk In September 2020, a retrospective study of 39 patients with severe or life-threatening COVID-19 at Mount Sinai Hospital, New York, USA, showed a positive effect of convalescent plasma treatment when donor sera were screened for anti-SARS-CoV-2 spike IgG titres of 1:320 (ref.119). offered evidence that it is possible for symptoms to appear once patients have left a 14 day period of quarantine or active monitoring; the authors suggest that To keep your body constantly adapting and prevent plateaus, it's important to vary your workout Key Points. A street through time used with powerful instructional strategies. Its strongest winds are about 105 miles an hour (170 kilometers an hour). JAMA 323, 20892090 (2020). Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19. To obtain 14 days: a timeline article - mashroubs.com Teachers College Record, 99, 478-513. The virus seemed to have potentially adapted to mink by introducing a Y453F mutation into the spike protein RBD (in addition to other mutations). "It was certainly very strong and also was very large," Chris Landsea said later. If they use the vertical format, personal events could be on one side, world events on the other. Instructional Science, 30, 221-241. Lancet 395, 16951704 (2020). B. Bats and agaves make tequila possibleand theyre both at risk, This empress was the most dangerous woman in Rome. Science 369, 718 (2020). During the day: Floodwaters continue to pour into New Orleans from breaks in the city's levees. He's also worried that many new residents of Biloxi have no idea what they may soon be facing. The McLellan laboratory quickly followed with the structural analysis of the interaction, revealing the molecular interactions between the RBD of SARS-CoV-2 and human ACE2 (ref.4). Lipsitch, M., Grad, Y. H., Sette, A. WEDNESDAY, AUGUST 24. Why Nadir Occurs. Moderna https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-positive-interim-phase-1-data-its-mrna-vaccine (2020). An inflammatory cytokine signature predicts COVID-19 severity and survival. This led to the mass culling of mink in Denmark and, as a result, more attention started to be given to variant viruses, including Cluster 5 variants in Europe that carry the N439K mutationin the RBD. Agarwal, A. et al. Nat. Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana. Pfefferle, S. et al. Spinato, G. et al. Monday, Feb 21. Self, W. H. et al. Cody Rhodes Shockingly Leaves AEW on February 15, 2022. Sustained remissions with CD19-specific chimeric antigen receptor (CAR)-modified T cells in children with relapsed/refractory ALL. Med. 9:30 a.m.: New Orleans Mayor Ray Nagin issues a mandatory evacuation order. Science 370, 1339 (2020). Additional data, partially already suggesting that the virus could be neutralized by convalescent sera, were published shortly thereafter in March 2020 (refs17,18,19,20,21). Akiko Iwasaki. Science 369, 806 (2020). Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with a high attack rate. Of course, the publication timeline can be tentative since some steps in the journal publication process, like peer review periods, can be difficult to estimate. Braun, J. et al. A study that measured cytokine levels in 1,484 patients with COVID-19 in New York, USA, found that high serum levels of IL-6, IL-8 and TNF at the time of hospitalization were strong and independent predictors of patient mortality105. Orthogonal SARS-CoV-2 serological assays enable surveillance of low-prevalence communities and reveal durable humoral immunity. The first description of 41 patients with what we now term COVID-19 (the name for the new disease being announced by the WHO on 11 February 2020) in Wuhan listed the most common symptoms at onset of disease as fever, cough, myalgia and fatigue7. Pezzini, A. Although interferons are highly potent at blocking SARS-CoV-2 replication, SARS-CoV-2 has an arsenal of evasion mechanisms to block the induction of endogenous interferons and interferon receptor signalling129,130. The disease has been renamed several times during 2020 to now be called multisystem inflammatory syndrome in children (MIS-C). Wassie, G., Azene, A., Bantie, G., Dessie, G. & Aragaw, A. Incubation period of severe acute respiratory syndrome novel coronavirus 2 that causes coronavirus disease 2019: a systematic review and meta-analysis. The weather system is about 350 miles (560 kilometers) east of Miami. By contrast, none of the 663 patients with asymptomatic or mild COVID-19 and only 4 of the 1,227 (0.3%) healthy donors had auto-antibodies to type I interferon. However, another study that examined pre-pandemic sera from PCR-confirmed cases of HCoV-OC43, HCoV-NL63 or HCoV-229E infection in Scotland found no cross-neutralizing antibodies to SARS-CoV-2 (ref.73). Read a detailed timeline of the Holocaust and World War II. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. Preprint at medRxiv https://doi.org/10.1101/2021.01.21.21249176 (2021). Med. By the end of February 2020, COVID-19 had already registered 83,652 cases globally16, roughly 10 times the global case count of the entire 20022003 SARS outbreak. The authors estimated that human-to-human transmission of SARS-CoV-2 had been occurring since mid-December 2019 (ref.11). Protoc. Nature 583, 290295 (2020). Cell 183, 982995.e914 (2020). The lesions (indicated by red arrow) of CT scan detected on day 3 after symptom onset (a).Axial images showed bilateral ground-glass opacity and consolidation on day 9 (b) and the larger area of lesions were observed on day 10 (c).CT scan on day 17 showed significant improvement of lesions before the first discharge (d), and on day 27 at relapse Most peoples symptoms appear around day five, on average. By contrast, a robust early interferon response is likely essential in controlling COVID-19. In June of 2020, Long et al.88 published a report showing that 40% of asymptomatically infected individuals lost their (mostly) anti-nucleoprotein antibody titres in a non-quantitative assay over an 8-week period. The first people were the pirates. PubMed Central Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. The center of the storm is about 225 miles (360 kilometers) from the mouth of the Mississippi River. Science 69, 818823 (2020). Millions of people around the United States and the world have been vaccinated against COVID-19, and the number of people being vaccinated each day continues to rise. Emerg. J. Med. Leppkes, M. et al. Nat. Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: a randomized clinical trial. N. Engl. Dis. Immunologists and virologists who were previously working on basic science have reached out and collaborated with physicians, nurses, epidemiologists, biostatisticians and computer scientists. Google Scholar. BMC Public Health 18, 574 (2018). Curr. 14 days: a timeline article - lovelybrations.com The median incubation period was calculated in 17 studies ranging from 2 to 12 days with an IQR lower bound of 2 days and higher bound of 14 days. Eco-friendly burial alternatives, explained. Thiago Carvalho, Florian Krammer &. Wrapp, D. et al. With the outcome of the Kanalkampf phase of the battle inconclusive, Gring made plans for an all-out assault against Fighter Command on the British mainland. Masterman, E., & Rogers, Y. Authentic assessment of timelines could include a guideline for the elements expected in each timeline, which could also serve as a self-editing checklist for students as they produce the timeline. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Students can begin with timelines of their own lives. Hammer, A. S. et al. You are using a browser version with limited support for CSS. Construct a timeline frame for struggling students and use templates for gathering information that will be placed on a personal timeline. 3) 4-methylpent-1-ene reacts with hydrogen bromide (identify major and minor products if necessary) 2) 2 moles of Fluorine gas react with 2-methylpropane (provide at least two structural isomers) Late Sunday night: Thousands of New Orleans residents who are unable to leave town or have chosen not to leave seek shelter in the Louisiana Superdome. Social Education, 61, 13-16. We have more than 5,000 books in our library! Rajasingham, R. et al. Med. Nat. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Characteristics of SARS-CoV-2 and COVID-19, Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine, A systematic review of SARS-CoV-2 vaccine candidates, The trinity of COVID-19: immunity, inflammation and intervention, https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200228-sitrep-39-covid-19.pdf?sfvrsn=5bbf3e7d_4, https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-first-participant-dosed-nih-led-phase-1-study, https://www.sanofi.com/en/media-room/press-releases/2020/2020-04-27-12-58-00, https://doi.org/10.1101/2021.01.07.21249390, https://www.cas.mhra.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=103134, https://doi.org/10.1101/2020.12.01.20241364, https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-positive-interim-phase-1-data-its-mrna-vaccine, https://www.pfizer.com/news/press-release/press-release-detail/pfizer_and_biontech_dose_first_participants_in_the_u_s_as_part_of_global_covid_19_mrna_vaccine_development_program, https://doi.org/10.1101/2020.11.06.20227215, https://doi.org/10.1101/2020.07.18.20155374, https://doi.org/10.1101/2020.11.15.383661, https://www.recoverytrial.net/news/statement-from-the-recovery-trial-chief-investigators-15-january-2021-recovery-trial-closes-recruitment-to-convalescent-plasma-treatment-for-patients-hospitalised-with-covid-19, https://doi.org/10.1101/2020.10.21.20216192, https://doi.org/10.1101/2020.12.28.20248807, https://doi.org/10.1101/2020.12.10.20247205, https://doi.org/10.1101/2021.01.21.21249176, https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563, https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial, https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3, https://doi.org/10.1038/s41586-021-03207-w, https://doi.org/10.1101/2020.12.28.424451, https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against, https://investors.modernatx.com/news-releases/news-release-details/modernas-covid-19-vaccine-candidate-meets-its-primary-efficacy, https://sputnikvaccine.com/newsroom/pressreleases/second-interim-analysis-of-clinical-trial-data-showed-a-91-4-efficacy-for-the-sputnik-v-vaccine-on-d/, https://nytimes.com/2020/12/30/business/china-vaccine.html, https://asia.nikkei.com/Spotlight/Coronavirus/UAE-announces-Sinopharm-vaccine-has-86-efficacy-against-COVID-19, https://www.reuters.com/article/us-health-coronavirus-china-vaccine/cansinos-covid-19-vaccine-candidate-approved-for-military-use-in-china-idUSKBN2400DZ, https://doi.org/10.1101/2020.07.04.187583, A strategy for evaluating potential antiviral resistance to small molecule drugs and application to SARS-CoV-2, Microbead-based extracorporeal immuno-affinity virus capture: a feasibility study to address the SARS-CoV-2 pandemic, Timing of surgery and elective perioperative management of patients with previous SARS-CoV-2 infection: a SIAARTI expert consensus statement, Summarising data and factors associated with COVID-19 related conspiracy theories in the first year of the pandemic: a systematic review and narrative synthesis, Moving toward a common goal via cross-sector collaboration: lessons learned from SARS to COVID-19 in Singapore, Cancel However, an open-label, RCT of convalescent plasma in 103 patients with severe or life-threatening COVID-19 failed to show significant benefits, as reported in June 2020 (ref.117). Elementary School Journal, 103,161-185. Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Nat. In the meantime, to ensure continued support, we are displaying the site without styles Analysis of the B cells specific for SARS-CoV-2 spike protein in a single patient 21 days after the onset of clinical disease found only a small number of somatic mutations, even though the patient had high serum titres of anti-spike antibodies100. Using a new tool called Rapid Extracellular Antigen Profiling (REAP), in December 2020, Wang et al.124 identified a wide range of autoantigens targeted by antibodies in patients with severe COVID-19. Lines and paragraphs break automatically. 14 days a timeline article tr wu. 11 a.m.: The hurricane's eye comes ashore again near the Louisiana-Mississippi border. Zhang, Q. et al. & Haghbayan, H. Interleukin-6 in Covid-19: a systematic review and meta-analysis. 129, 104511 (2020). Creating a journal publication schedule (Download Template) 77, 683690 (2020). 14 Days - A Timeline | The Storm | FRONTLINE | PBS Nat Rev Immunol 21, 245256 (2021). JAMA 323, 15821589 (2020). In addition, a small number of reinfections were starting to be reported89,90. Its strongest winds are blowing at about 40 miles an hour (65 kilometers an hour). Chandrashekar, A. et al. It is well known that, for most RNA viruses, escape mutants can be relatively quickly selected under pressure from a single monoclonal antibody but that using two monoclonal antibodies avoids this issue. In the last few minutes of his closing arugments, lead prosecutor Creighton Waters grew quiet and somber. N. Engl. 21, 15061516 (2020). Sputnik V. Second interim analysis of clinical trial data showed a 91.4% efficacy for the Sputnik V vaccine on day 28 after the first dose; vaccine efficacy is over 95% 42 days after the first dose. The efficacy of most therapies for COVID-19 has been shown to vary greatly across disease stages. Here, we used droplet emulsion microfluidics with temperature control and dead-volume minimization to rapidly generate thousands of micro-organospheres (MOSs) from low-volume patient tissues, which serve as an ideal patient-derived model for clinical precision oncology. April 3: Ontario projects COVID-19 death toll could reach 15,000. Remdesivir for the treatment of Covid-19 final report. Highlighting critical points in time. However, over the past 12months, we have gained incredible insights into the innate and adaptive immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and have brought to fruition the development of multiple vaccines against the virus. The storm's top winds are 80 miles an hour (130 kilometers an hour). The Holocaust and World War II: Key Dates While chemotherapy directly targets cancer cells, it also affects other normal rapidly dividing cells in the process. Amidst all this, science was conducted at an unprecedented speed and vaccines were developed, tested and approved within 11 months. Kindergarten students could use the first line of the template provided, either writing their birth date themselves or telling it to someone for dictation. 2 a.m.: Hurricane Katrina turns north toward the Louisiana coast, but the storm's strongest winds have diminished slightly to about 155 miles an hour (250 kilometers an hour). Switch things up after six to 12 weeks. Some of these vaccines (SputnikV and CanSino) had already been used in Russia and China, respectively, even before phase III data were available156,157. Mateus, J. et al. 9, 291300 (2009). On the last day of 2019, the WHO Country Office in China was notified of a cluster of cases of a novel viral pneumonia of unknown cause in Wuhan City, Hubei province. T cell lymphopenia is observed. PubMed Tao, Y. et al. calendar, any system for dividing time over extended periods, such as days, months, or years, and arranging such divisions in a definite order. Children reading pictures: History visuals at key stages 1 and 2. 11:30 a.m.: The National Hurricane Center reports that the hurricane is "rapidly strengthening" as it crosses the Gulf of Mexico's very warm waters. Lumley, S. F. et al. MHRA. Consistently, patients with MIS-C have increased levels of IgG+ plasmablasts in circulation and increased levels of IgG capable of binding to human cardiac microvascular endothelial cells55. Consistent with Woodruff et al.113, Kaneko et al.112 also reported increased levels of extrafollicular IgDCD27 B cells, which are also found in autoimmune diseases such as SLE, in their COVID-19 post-mortem lymph node and spleen samples. Iyer, A. S. et al. 3 p.m.: The center of the hurricane is about 20. J. Virol. Thevarajan, I. et al. Johnson & Johnson announces single-shot Janssen COVID-19 vaccine candidate met primary endpoints in interim analysis of its phase 3 ENSEMBLE trial. 14 days: a timeline article Jun 12, 2022beauty appeal in advertising If there is a total of less than 50 new cases of COVID-19 per 100,000 residents over 14 days, He cautioned against using just one day or a "snapshot" in time as a basis for reopening. Zhang, X. M., Herbst, W., Kousoulas, K. G. & Storz, J. Virus Res. Li, Q. et al. Patients with COVID-19 who have acute respiratory distress syndrome also have high rates of delirium and encephalopathy36. BMJ 370, m2516 (2020). May 10, 1940-June 22, 1940 Germany attacks western Europe, specifically France and the neutral Low Countries (Belgium, the Netherlands, and Luxembourg). This method uses the cells of the spreadsheet to create and format your own timeline. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Between January 15 and May 14, the students will This score is calculated based on Mean time to failure and Total usage duration (14 days). The new year once started in Marchhere's why, Jimmy Carter on the greatest challenges of the 21st century, This ancient Greek warship ruled the Mediterranean, How cosmic rays helped find a tunnel in Egypt's Great Pyramid, Who first rode horses? 14 days: a timeline articlenrl bulldogs news and rumours. Discovery of a novel coronavirus, China Rattus Coronavirus HKU24, from Norway rats supports the murine origin of betacoronavirus 1 and has implications for the ancestor of betacoronavirus lineage A. J. Virol. A single-cell atlas of the peripheral immune response in patients with severe COVID-19. April 3: Ontario projects COVID-19 death toll could reach 15,000. It's advisable to keep timelines fairly simple, to cocreate them with students, and to consider alternative chronological representations given the content taught, such as vertical or horizontal timelines, timelines at an angle, timelines that replicate a path taken by people or travelers, or circles (Alleman & Brophy, 2003; Lynn, 1993; Masterman & Rogers, 2002). 129, 104512 (2020). Furthermore, these results formalized the concept of stage-specific COVID-19 disease interventions87. There are many timeline examples that are commonly used for: Providing an overview of events. Timeline. d | Early post-exposure prophylaxis with recombinant type I interferon can reduce the viral load of SARS-CoV-2 and hasten recovery. The mechanism behind this phenomenon is unknown. Marcus Morgan, 14, waits to receive his Pfizer COVID-19 vaccine at Families Together of Orange County in Tustin, Calif., on May 13, 2021. Vaccination with bacillus CalmetteGurin (BCG), a live attenuated vaccine against tuberculosis, reduces childhood mortality caused not only by tuberculosis but also owing to unrelated infections. The authors predicted that this lack of interferon responses would enable sustained viral replication and lead to serious SARS-CoV-2 infection. Novavax COVID-19 vaccine demonstrates 89.3% efficacy in UK phase 3 trial. For all the reactions, identify the reaction type and name the products formed. J. Clin. Preprint at medRxiv https://doi.org/10.1101/2020.07.18.20155374 (2020). A recommended approach to creating a publication timeline that ensures a seamless journal publication process is to work backwards from the target date of publication. Pinto, D. et al. In addition to children with MIS-C, autoreactive antibodies have also been observed in adult patients with COVID-19. JAMA 324, 460470 (2020). 3) Reaction of pentan-3-one with NaAlB4 Early transmission dynamics in Wuhan, China, of novel coronavirusinfected pneumonia. Nat. Immunity 53, 925933.e4 (2020). These are historical moments for science and immunology. J. Med. At 7 am Katrina is a Category 5 with 160 mph maximum sustained winds. Dozens of carefully selected booklists, for kids 0-12 years old, Nonfiction for Kids Dynamics of neutralizing antibody titers in the months after severe acute respiratory syndrome coronavirus 2 infection. Coronavirus: A timeline of how the deadly outbreak is evolving Hung, I. F. et al. Juno, J. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Interleukin-6 receptor antagonists in critically ill patients with Covid-19 preliminary report. Model a template on a piece of chart paper using one student as an example, and then each student could complete their own template: "In I" completing one for each year of the timeline. Haas, M. (2000). . Hadjadj, J. et al. Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. 5 p.m.: The National Hurricane Center describes Katrina as a "potentially catastrophic" hurricane. Two studies from Casanova and collaborators first published on 24September 2020 showed, unequivocally, that type I interferon induction and signalling have key roles in preventing lethal COVID-19. By ro. Moraleda, C. et al. Huang et al.7 also reported that 26 of the 41 patients had lymphopenia and that those admitted to the ICU had increased plasma levels of cytokines and chemokines, specifically IL-2, IL-7, IL-10, granulocyte colony-stimulating factor (GCSF; also known as CSF3), CC-chemokine ligand 2 (CCL2; also known as MCP1) and tumour necrosis factor (TNF). Cell Rep. 33, 108234 (2020). Barton, K. C. (2008). Science 370, 1227 (2020). Click anywhere in the Pivot table and go to the Insert tab. In the first column I put the date and/or time of an event; in the second is put a short description of the event; and in the third goes the source of the date and event. During the day: A convoy of U.S. National Guard troops and supply trucks arrives in New Orleans and distributes food and water to residents stranded at the Superdome and convention center. Preprint at SSRN https://doi.org/10.2139/ssrn.3712813 (2020). SARS-CoV-2 infection protects against rechallenge in rhesus macaques. Pfizer & BioNTech. ), Handbook of research on social studies teaching and learning (pp. PubMed Interim results from AstraZeneca of their viral-vectored ChAdOx1 vaccine followed suit on 8December 2020, showing an overall vaccine efficacy of 70.4% across two cohorts151. Nat. How could you also describe the world you live in?" Here is another example: 2020.48.37.2. "This is going to be an unprecedented event.". Biotechnol. Then came the Indians and the Pilgrims. Rambaut, A. et al. 57, e100 (2020). Res. Surveillance of bat coronaviruses in Kenya identifies relatives of human coronaviruses NL63 and 229E and their recombination history. Sputnik https://sputnikvaccine.com/newsroom/pressreleases/second-interim-analysis-of-clinical-trial-data-showed-a-91-4-efficacy-for-the-sputnik-v-vaccine-on-d/ (2020). A cluster-randomized trial of hydroxychloroquine for prevention of Covid-19. Med. Reuters. jason beghe political views; national wild turkey federation stamp collection; publix fruit cake price; john vandemoer lawyer; Social Studies and the Young Learner, 13(2), 20-23. 14 days: a timeline article. This deficit was particularly pronounced among women at more advanced stages of their career166. Squazzoni, F. et al. Materials Computer with Internet access 14 Days: A Timeline article Assignment Instructions For this project, you are expected to submit two (2) items: 1. Bastard et al.127 found that 135 of 987 (13.7%) patients with severe COVID-19 had antibodies to IFN, IFN or both, a finding that was later confirmed by another study124. Ther. . Dis. Animal models for COVID-19. Infect. Assessment of SARS-CoV-2 serological tests for the diagnosis of COVID-19 through the evaluation of three immunoassays: Two automated immunoassays (Euroimmun and Abbott) and one rapid lateral flow immunoassay (NG Biotech). Alleman, J., & Brophy, J. The timing and route of the interferon therapy seem to be key, as an interim report from the WHO Solidarity Trial, an open label trial in which patients of all stages of disease who were hospitalized were randomly assigned to receive subcutaneous IFN1a or other repurposed antivirals, showed little or no effect of interferon therapy on overall mortality, initiation of ventilation or duration of hospital stay85. Hydroxychloroquine with or without azithromycin in mild-to-moderate Covid-19. Science 369, 812 (2020). Wee, S. L. & Qin, A. Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome cCoronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial.